Projects

THE FRANCIS CRICK INSTITUTE LIMITED -  

Project overview (since 2010-01-01):

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Start dateProjectacronymrolefundingpartners
2023-01-01Role of dynamic JNK signalling in balancing cell removal and renewal in a stressed epithelium JNK_Life.Deathcoordinator212.9341
2022-09-01Unravelling the mechanism of eukaryotic helicase activation MechHelicaseActiv8oncoordinator212.9341
2022-09-01Molecular dynamics of size sensing at the single cell level. SizerSingleCellcoordinator212.9341
2022-05-01Mechanism of Chromatin Replication MeChroRepcoordinator1.723.5141
2021-12-01Pinpointing novel molecular and cellular functions generated by retroelement onco-exaptation RETROFITcoordinator2.483.6911
2021-10-01Understanding and controlling the spatial organisation of cancer CAN_ORGANISEcoordinator2.500.0001
2021-09-01Metabolic mechanisms underpinning obesity-driven pancreatic cancer PancObesecoordinator2.500.0001
2021-09-01Mechanisms underlying regulation and removal of G-quadruplex/R-loop transcription-replication conflicts GLoopIDcoordinator224.9341
2021-08-01Divide and conquer: using patient-derived tumour organoids to dissect intra-tumour immune heterogeneity of non-small cell lung cancer TxImmuneOrganoidscoordinator224.9341
2021-06-01Revolutionary Platform to Decipher Immunogenicity of Tumour Neoantigens- the Ultimate Targets for Future Immunotherapies to Eradicate Cancer DECOD-Agparticipant2.999.9945
2021-06-01Dynamic regulation of tissue response by matrix viscoelasticity VISCOMATRIXparticipant1.499.9892
2021-04-01Deciphering the mechanism of the dual functional E3 ligase TRIM28 in cancer cells TRIM MAGE complexescoordinator212.9341
2021-04-01Molecular analysis of the properties of human Arp2/3 complex family members MolecularArpcoordinator212.9341
2020-08-01Prefrontal Cortex Circuit Dynamics underlying Working Memory and its Serotonin Modulation PIANISMcoordinator212.9342
2020-07-01Understanding Serotonergic Regulation of Working Memory SERWOMcoordinator212.9342
2020-07-01Metabolic Regulation of Conventional Dendritic Cell Development and Function DC Metabolismcoordinator212.9341
2020-04-01MRTF/SRF signalling in regulation of cell senescence and melanoma progression MRTFSencoordinator224.9341
2020-04-01Modelling the Predictability and Repeatability of Tumour Evolution in Clear Cell Renal Cell Cancer RCC_Evocoordinator224.9341
2020-04-01Deciphering the mechanism of irreversible replication fork arrest Irrev Fork Arrestcoordinator212.9341
2020-04-01Tracking the movement and dynamics of Holliday junctions HollidayTrackcoordinator212.9341
2020-04-01Single-cell spatiotemporal analysis of Mycobacterium tuberculosis responses to antibiotics within host microenvironments SpaTime_AnTBcoordinator224.9341
2020-01-01Multivalent interactions driving RNP dynamics in development and disease RNPdynamicsparticipant2.396.2614
2020-01-01Identification and characterization of enteric nervous system stem cells IDENSTEMcoordinator212.9341
2019-12-01Neural adaptations during pregnancy PregnantBraincoordinator1.494.3931
2019-11-01Ancient genomic reconstruction of convergent evolution to agriculture AGRICONcoordinator1.500.0001
2019-11-01Origin: reconstructing African prehistory using ancient DNA ORIGINcoordinator212.9341
2019-08-01Targeting RAS driven tumour immune evasion RASImmunecoordinator2.500.0001
2019-07-01Deciphering the mechanisms of antiviral RNA interference in mammals UncoveRNAicoordinator212.9341
2019-07-01Defining the role of Arp2/3 complex diversity at multiple scales of biology ArpComplexitycoordinator10.715.1533
2019-06-01Predicting Routes Of Tumour Evolution driven by Unstable genomes and Selection PROTEUScoordinator2.500.0001
2019-06-01Studying RNA-binding proteins involved in neural differentiation and degeneration NeuroRBPcoordinator195.4551
2019-05-01The role of ASCL1 and MYCN in human brain development mAMBocoordinator212.9341
2019-04-01Constructing an evolutionary atlas of the immune landscape in lung cancer TRACERxTMEcoordinator212.9341
2019-04-01Cryo-EM Imaging of Histone Recycling at the Replication Fork Cryo-H-Reccoordinator212.9341
2019-04-01Mechanisms of human DNA replication Human Repl Mechcoordinator212.9341
2019-03-01Chromosome Replication Visualised by Cryo-EM CRYOREPcoordinator2.000.0001
2019-03-01Cellular and genetic bases of neural circuits evolution EvolutioNeuroCircuitcoordinator1.312.5001
2019-01-01Identification and characterization of a novel damage sensor for cytoskeletal proteins in Drosophila ActinSensorcoordinator195.4551
2018-09-01Steady-state and demand-driven dendritic cell generation DCPOIESIScoordinator2.500.0001
2018-09-01Spatiotemporal regulation of localization and replication of M. tuberculosis in humanmacrophages DynaMO_TBcoordinator2.000.0001
2018-07-01In vitro high resolution reconstitution of autophagosome nucleation and expansion catalyzed byATG9 ATG9_SOLVES_ITcoordinator2.121.0551
2018-03-01Unravelling gamma delta T cell emergence and responses in the uterus UTERUScoordinator183.4551
2018-03-01Mechanical and systemic control of growth during Drosophila abdominal development GrowthControlcoordinator183.4551
2018-01-01The molecular and cellular logic of vertebrate neural development LogNeuroDevcoordinator2.357.0001
2018-01-01Role of perforin-like proteins and phospholipases in malaria parasite egress MalariaEgresscoordinator183.4551
2017-09-01Telomere metabolism in Genome Stability and Disease TelMetabcoordinator2.118.4311
2017-06-01RAS/C-RAF interaction: A new pharmacological target in Kras-driven lung cancer. IVORIaNcoordinator183.4551
2017-04-01Hold it or let it go: a niche decision on cancer growth WHOLENICHEparticipant2.000.0001
2017-04-01SIngle-cell multi-OMICs approach to study intra-tumour heterogeneity of soft tissue Sarcomas SIOMICScoordinator195.4551
2017-03-01Visual and vestibular processing in secondary visual cortex VestibViscoordinator183.4551
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